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Under the Mistletoe: How Kissing Affects Your Brain

Mihaela Raileanu
5 min readJan 19, 2025

Kissing is a universal gesture.

Lovebirds, like humans, use kissing-like behaviors to strengthen bonds and express affection, highlighting the universality of connection. Photo source: unsplash.com

It’s an expression of love, affection, or even passion. But what happens in our brain when we kiss? And why do holiday kisses — under the mistletoe or by the glow of a Christmas tree — feel extra special? Neuroscience offers some fascinating answers 💋.

What Happens in the Brain When We Kiss?

A kiss is more than just a romantic gesture — it’s a profound experience that has remarkable effects on the chemistry of our brain. When our lips meet someone else’s, a cascade of biological reactions is triggered, enhancing our sense of well-being. Dopamine, known as the “pleasure hormone,” is released, giving us a sense of reward and euphoria. That electrifying thrill that leaves us on cloud nine? Thank dopamine for that.

Simultaneously, oxytocin, often called the “love hormone,” plays a crucial role in strengthening emotional connections between partners. It fosters a deep sense of closeness and trust, helping build lasting bonds. Serotonin, the happiness hormone, also contributes by regulating mood and creating a sense of calm and inner balance. Together, this chemical trio transforms a simple kiss into a moment of intense happiness.

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Mihaela Raileanu
Mihaela Raileanu

Written by Mihaela Raileanu

Researcher, writer, explorer of ideas. I write about films (Lord of the Rings, Game of Thrones) and how we can create a better world. Join for fresh insights!

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